Article
Germline activating TYK2 mutations in pediatric patients with two primary acute lymphoblastic leukemia occurrences.
Leukemia - 1 Apr 2017
Waanders E, Scheijen B, Jongmans M C J, Venselaar H, van Reijmersdal S V, van Dijk A H A, Pastorczak A, Weren R D A, van der Schoot C E, van de Vorst M, Sonneveld E, Hoogerbrugge N, van der Velden V H J, Gruhn B, Hoogerbrugge P M, van Dongen J J M, Geurts van Kessel A, van Leeuwen F N, Kuiper R P
Abstract excerpt
The contribution of genetic predisposing factors to the development of pediatric acute lymphoblastic leukemia (ALL), the most frequently diagnosed cancer in childhood, has not been fully elucidated. Children presenting with multiple de novo leukemias are more likely to suffer from genetic predisposition. Here, we selected five of these patients and analyzed the mutational spectrum of normal and malignant tissues....
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