Article
Inherited coding variants at the CDKN2A locus influence susceptibility to acute lymphoblastic leukaemia in children.
Nature communications - 24 Jun 2015
Xu Heng, Zhang Hui, Yang Wenjian, Yadav Rachita, Morrison Alanna C, Qian Maoxiang, Devidas Meenakshi, Liu Yu, Perez-Andreu Virginia, Zhao Xujie, Gastier-Foster Julie M, Lupo Philip J, Neale Geoff, Raetz Elizabeth, Larsen Eric, Bowman W Paul, Carroll William L, Winick Naomi, Williams Richard, Hansen Torben, Holm Jens-Christian, Mardis Elaine, Fulton Robert, Pui Ching-Hon, Zhang Jinghui, Mullighan Charles G, Evans William E, Hunger Stephen P, Gupta Ramneek, Schmiegelow Kjeld, Loh Mignon L, Relling Mary V, Yang Jun J
Abstract excerpt
There is increasing evidence from genome-wide association studies for a strong inherited genetic basis of susceptibility to acute lymphoblastic leukaemia (ALL) in children, yet the effects of protein-coding variants on ALL risk have not been systematically evaluated. Here we show a missense variant in CDKN2A associated with the development of ALL at genome-wide significance (rs3731249, P=9.4 × 10(-23), odds...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.