Article
TYK2 Variants in B-Acute Lymphoblastic Leukaemia.
Genes - 28 Nov 2020
Turrubiartes-Martínez Edgar, Bodega-Mayor Irene, Delgado-Wicke Pablo, Molina-Jiménez Francisca, Casique-Aguirre Diana, González-Andrade Martín, Rapado Inmaculada, Camós Mireia, Díaz-de-Heredia Cristina, Barragán Eva, Ramírez-Orellana Manuel, Aguado Beatriz, Figuera Ángela, Martínez-López Joaquín, Fernández-Ruiz Elena
Abstract excerpt
B-cell precursor acute lymphoblastic leukaemia (B-ALL) is a malignancy of lymphoid progenitor cells with altered genes including the Janus kinase (JAK) gene family. Among them, tyrosine kinase 2 (TYK2) is involved in signal transduction of cytokines such as interferon (IFN) α/β through IFN-α/β receptor alpha chain (IFNAR1). To search for disease-associated TYK2 variants, bone marrow samples from 62 B-ALL patients...
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