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Article

Tyrosine kinase 2 - Surveillant of tumours and bona fide oncogene.

Cytokine - 1 Jan 2017

Leitner Nicole R, Witalisz-Siepracka Agnieszka, Strobl Birgit, Müller Mathias

Abstract excerpt

Tyrosine kinase 2 (TYK2) is a member of the Janus kinase (JAK) family, which transduces cytokine and growth factor signalling. Analysis of TYK2 loss-of-function revealed its important role in immunity to infection, (auto-) immunity and (auto-) inflammation. TYK2-deficient patients unravelled high similarity between mice and men with respect to cellular signalling functions and basic immunology. Genome-wide...

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Source

Identifiers

PMID: 26631911
DOI: 10.1016/j.cyto.2015.10.015

Genes

TYK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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