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Article

TYK2: An Upstream Kinase of STATs in Cancer

5 Nov 2019

Abstract excerpt

In this review we concentrate on the recent findings describing the oncogenic potential of the protein tyrosine kinase 2 (TYK2). The overview on the current understanding of TYK2 functions in cytokine responses and carcinogenesis focusses on the activation of the signal transducers and activators of transcription (STAT) 3 and 5. Insight gained from loss-of-function (LOF) gene-modified mice and human patients...

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PMID: 31694222
DOI: 10.3390/cancers11111728

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