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Article

The functional role of inherited CDKN2A variants in childhood acute lymphoblastic leukemia.

Pharmacogenetics and genomics - 1 Feb 2022

Li Chunjie, Zhao Xinying, He Yingyi, Li Ziping, Qian Jiabi, Zhang Li, Ye Qian, Qiu Fei, Lian Peng, Qian Maoxiang, Zhang Hui

Abstract excerpt

OBJECTIVE: Genetic alterations in CDKN2A tumor suppressor gene on chromosome 9p21 confer a predisposition to childhood acute lymphoblastic leukemia (ALL). Genome-wide association studies have identified missense variants in CDKN2A associated with the development of ALL. This study systematically evaluated the effects of CDKN2A coding variants on ALL risk. METHODS: We genotyped the CDKN2A coding region in 308...

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Identifiers

PMID: 34369425
DOI: 10.1097/FPC.0000000000000451
PMCID: PMC8694244

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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