Article
JAK mutations in high-risk childhood acute lymphoblastic leukemia.
Proceedings of the National Academy of Sciences of the United States of America - 9 Jun 2009
Mullighan Charles G, Zhang Jinghui, Harvey Richard C, Collins-Underwood J Racquel, Schulman Brenda A, Phillips Letha A, Tasian Sarah K, Loh Mignon L, Su Xiaoping, Liu Wei, Devidas Meenakshi, Atlas Susan R, Chen I-Ming, Clifford Robert J, Gerhard Daniela S, Carroll William L, Reaman Gregory H, Smith Malcolm, Downing James R, Hunger Stephen P, Willman Cheryl L
Abstract excerpt
Pediatric acute lymphoblastic leukemia (ALL) is a heterogeneous disease consisting of distinct clinical and biological subtypes that are characterized by specific chromosomal abnormalities or gene mutations. Mutation of genes encoding tyrosine kinases is uncommon in ALL, with the exception of Philadelphia chromosome-positive ALL, where the t(9,22)(q34;q11) translocation encodes the constitutively active BCR-ABL1...
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