Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Somatic mutations of JAK1 and JAK3 in acute leukemias and solid cancers.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jun 2008

Jeong Eun Goo, Kim Min Sung, Nam Hyo Kyung, Min Chang Ki, Lee Seok, Chung Yeun Jun, Yoo Nam Jin, Lee Sug Hyung

Abstract excerpt

PURPOSE: The aim of this study was to see whether JAK1, JAK3, and TYK2 genes are altered in human cancers. EXPERIMENTAL DESIGN: We analyzed 494 tissues from 186 acute adulthood leukemias, 30 multiple myelomas, and 278 common solid cancers, including 90 breast, 47 gastric, 47 colon, 47 lung, and 47 hepatocellular carcinomas by single-strand conformation polymorphism analysis. RESULTS: Overall, we found six JAK1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Disease
Share to Carcinoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colorectal Neoplasms

Share to Janus Kinase 1

Share to Janus Kinase 3

Share to Leukemia

Share to Liver Neoplasms

Share to Stomach Neoplasms

Source

Identifiers

PMID: 18559588
DOI: 10.1158/1078-0432.CCR-07-4839

Genes

JAK1
JAK3
JAK2
TYK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Somatic mutations of JAK1 and JAK3 in acute leukemias and solid cancers.PMID 18559588Read ↗

Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia.Semantic proximity Read ↗

Identification of a novel functional JAK1 S646P mutation in acute lymphoblastic leukemia.Semantic proximity Read ↗

Recurrent JAK1 and JAK3 somatic mutations in T-cell prolymphocytic leukemiaSemantic proximity Read ↗

Newly described activating JAK3 mutations in T-cell acute lymphoblastic leukemia.Semantic proximity Read ↗

Janus Kinases in LeukemiaSemantic proximity Read ↗

Identification of somatic JAK1 mutations in patients with acute myeloid leukemia.Semantic proximity Read ↗

Germline activating TYK2 mutations in pediatric patients with two primary acute lymphoblastic leukemia occurrences.Semantic proximity Read ↗

JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model.Semantic proximity Read ↗

[Research advances in the role of JAK2 mutations in acute leukemia].Semantic proximity Read ↗

Mining for JAK-STAT mutations in cancer.Semantic proximity Read ↗

JAK mutations in high-risk childhood acute lymphoblastic leukemia.Semantic proximity Read ↗

Association of Janus kinase 2 (JAK2) polymorphisms with acute leukemia susceptibility.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.