Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia.

doi:10.1084/jem.20072182

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Article

Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia.

The Journal of experimental medicine - 14 Apr 2008

Flex Elisabetta, Petrangeli Valentina, Stella Lorenzo, Chiaretti Sabina, Hornakova Tekla, Knoops Laurent, Ariola Cristina, Fodale Valentina, Clappier Emmanuelle, Paoloni Francesca, Martinelli Simone, Fragale Alessandra, Sanchez Massimo, Tavolaro Simona, Messina Monica, Cazzaniga Giovanni, Camera Andrea, Pizzolo Giovanni, Tornesello Assunta, Vignetti Marco, Battistini Angela, Cavé Hélène, Gelb Bruce D, Renauld Jean-Christophe, Biondi Andrea, Constantinescu Stefan N, Foà Robin, Tartaglia Marco

Abstract excerpt

Aberrant signal transduction contributes substantially to leukemogenesis. The Janus kinase 1 (JAK1) gene encodes a cytoplasmic tyrosine kinase that noncovalently associates with a variety of cytokine receptors and plays a nonredundant role in lymphoid cell precursor proliferation, survival, and differentiation. We report that somatic mutations in JAK1 occur in individuals with acute lymphoblastic leukemia (ALL)....

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Identifiers

PMID: 18362173
DOI: 10.1084/jem.20072182
PMCID: PMC2292215

Genes

JAK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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