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Article

Irreversible splenic atrophy following chronic LCMV infection is associated with compromised immunity in mice.

European journal of immunology - 1 Jan 2017

Mbanwi Achire N, Wang Chao, Geddes Kaoru, Philpott Dana J, Watts Tania H

Abstract excerpt

Lymphocytic choriomeningitis virus clone 13 (LCMV13) infection of mice is a widely used model for investigating the mechanisms driving persistent viral infection in humans. LCMV13 disrupts splenic architecture early during infection, but this returns to normal within a few weeks. However, the long-term effects of LCMV13 infection on splenic structure have not been reported. Here, we report that persistent...

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Identifiers

PMID: 27730627
DOI: 10.1002/eji.201646666

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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