Back to search

Article

Alterations in Germinal Center Formation and B Cell Activation during Severe <i>Orientia tsutsugamushi</i> Infection in Mice

2023-01-13

Abstract excerpt

Scrub typhus is a poorly studied but life-threatening disease caused by the intracellular bacterium Orientia tsutsugamushi ( Ot ). Cellular and humoral immunity in Ot -infected patients is not long-lasting, waning as early as one-year post-infection; however, its underlying mechanisms remain unclear. To date, no studies have examined germinal center (GC) or B cell responses in Ot -infected humans or experiment...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
f2cd978b-dada-55b4-b169-91a3d519eb49
DOI
10.1101/2023.01.12.523709
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Alterations in Germinal Center Formation and B Cell Activation during Severe <i>Orientia tsutsugamushi</i> Infection in MiceDOI 10.1101/2023.01.12.523709
Unique B Cell and Germinal Center Responses in Mice with Severe versus Mild <i>Orientia tsutsugamushi</i> InfectionSemantic proximity
Host transcriptomic profiling of CD-1 outbred mice with severe clinical outcomes following infection with <i>Orientia tsutsugamushi</i>Semantic proximity
Selective Activation of Macrophage Innate Signaling Pathways and Inflammatory Responses to <i>Orientia tsutsugamushi</i> Karp and Gilliam StrainsSemantic proximity
An Update on Host-Pathogen Interplay and Modulation of Immune Responses during Orientia tsutsugamushi InfectionSemantic proximity
Differential cellular immune responses against <i>Orientia tsutsugamushi</i> Karp and Gilliam strains following acute infection in miceSemantic proximity
Polarized Lung Inflammation and Tie2/Angiopoietin-Mediated Endothelial Dysfunction during Severe <i>Orientia tsutsugamushi</i> InfectionSemantic proximity
A Humanized IFN-γ Mouse Model Reveals Skin Eschar Formation, Enhanced Susceptibility and Scrub Typhus PathogenesisSemantic proximity
Dissecting the developmental life cycle and developing genetic tools for understanding the biology of Orientia tsutsugamushiSemantic proximity
Orientia Tsutsugamushi Infection Stimulates Syk-Dependent Responses and Innate Cytosolic Defenses in MacrophagesSemantic proximity
Comparative virulence analysis of seven diverse strains of <i>Orientia tsutsugamushi</i> reveals a multifaceted and complex interplay of virulence factors responsible for diseaseSemantic proximity
The Obligate Intracellular Bacterium Orientia tsutsugamushi Targets NLRC5 To Modulate the Major Histocompatibility Complex Class I PathwaySemantic proximity
A genome-wide RNAi screen identifies host cell cycle regulation as a determinant of <i>Orientia tsutsugamushi</i> infectionSemantic proximity
Select a neighboring publication to make it the new centre.