Article
Longitudinal Analysis of the Phenotype, Transcriptional Profile, and Anatomic Location of Memory CD8 T Cell Subsets after Acute Viral Infection.
Journal of virology - 31 Jan 2023
Gill Amanda L, Hudson William H, Valanparambil Rajesh M, Ahn Eunseon, McGuire Donald J, Wieland Andreas, McManus Daniel T, Kissick Haydn T, Akondy Rama S, Ahmed Rafi
Abstract excerpt
Increased demand for novel, highly effective vaccination strategies necessitates a better understanding of long-lived memory CD8 T cell differentiation. To achieve this understanding, we used the mouse model of acute lymphocytic choriomeningitis virus (LCMV) infection. We reexamined classical memory CD8 T cell subsets and performed in-depth, longitudinal analysis of their phenotype, transcriptional programming,...
Topics
- Animals
- Mice
- CD8-Positive T-Lymphocytes
- Immunologic Memory
- Lymphocytic Choriomeningitis
- Lymphocytic choriomeningitis virus
- Mice, Inbred C57BL
- Phenotype
- T-Lymphocyte Subsets
- Vaccination
- CD28 Antigens
- Transcriptome