Article
Persistence of virus-specific immune responses in the central nervous system of mice after West Nile virus infection.
BMC immunology - 20 Jan 2011
Stewart Barbara S, Demarest Valerie L, Wong Susan J, Green Sharone, Bernard Kristen A
Abstract excerpt
BACKGROUND: West Nile virus (WNV) persists in humans and several animal models. We previously demonstrated that WNV persists in the central nervous system (CNS) of mice for up to 6 months post-inoculation. We hypothesized that the CNS immune response is ineffective in clearing the virus. RESULTS: Immunocompetent, adult mice were inoculated subcutaneously with WNV, and the CNS immune response was examined at 1, 2,...
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