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Article

Age-related dysregulation of CD8+ T cell memory specific for a persistent virus is independent of viral replication.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2008

Lang Anna, Brien James D, Messaoudi Ilhem, Nikolich-Zugich Janko

Abstract excerpt

The immune system devotes substantial resources to the lifelong control of persistent pathogens, which were hypothesized to play an important role in immune aging. Specifically, the presence of latent herpesviruses has been correlated with immune exhaustion and shorter lifespan in octogenarians. But neither the causality nor the mechanistic link(s) were established, and the relative roles of persistent antigenic...

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Share to Aging
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Herpesvirus 1, Human

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Source

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Identifiers

PMID: 18354208
DOI: 10.4049/jimmunol.180.7.4848
PMCID: PMC4161215

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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