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Article

Fine-mapping the effects of Alzheimer's disease risk loci on brain morphology.

Neurobiology of aging - 1 Dec 2016

Roshchupkin Gennady V, Adams Hieab H, van der Lee Sven J, Vernooij Meike W, van Duijn Cornelia M, Uitterlinden Andre G, van der Lugt Aad, Hofman Albert, Niessen Wiro J, Ikram Mohammad A

Abstract excerpt

The neural substrate of genetic risk variants for Alzheimer's disease (AD) remains unknown. We studied their effect on healthy brain morphology to provide insight into disease etiology in the preclinical phase. We included 4071 nondemented, elderly participants of the population-based Rotterdam Study who underwent brain magnetic resonance imaging and genotyping. We performed voxel-based morphometry (VBM) on all...

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Identifiers

PMID: 27718423
DOI: 10.1016/j.neurobiolaging.2016.08.024

Genes

ABCA7
APOE
CLU
ZCWPW1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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