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Article

Neuroimaging PheWAS and molecular phenotyping implicate PSMC3 in Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Feb 2026

Bledsoe Xavier, Wang Ting-Chen, Wu Yiyang, Archer Derek, Chen Hung Hsin, Naj Adam C, Bush William S, Hohman Timothy J, Dumitrescu Logan, Below Jennifer E, Gamazon Eric R

Abstract excerpt

INTRODUCTION: Neuroimaging genetics has advanced our understanding of Alzheimer's disease (AD); however, frameworks using functional genomics are needed to elucidate mechanisms connecting loci to neurological outcomes. To address this need, we explored relationships between AD-associated variants and disease via their impact on gene expression and neuroanatomical phenotypes. METHODS: We mapped established AD...

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Identifiers

PMID: 41732108
DOI: 10.1002/alz.71217
PMCID: PMC12930104

Genes

PSMC3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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