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Article

Enlargement of the Axial Length and Altered Ultrastructural Features of the Sclera in a Mutant Lumican Transgenic Mouse Model.

PloS one - 1 Jan 2016

Song Yanzheng, Zhang Fengju, Zhao Yanyan, Sun Mingshen, Tao Jun, Liang Yanchuang, Ma Ling, Yu Yanqiu, Wang Jianhua, Hao Junfeng

Abstract excerpt

Lumican (LUM) is a candidate gene for myopia in the MYP3 locus. In this study, a mutant lumican (L199P) transgenic mouse model was established to investigate the axial length changes and ultrastructural features of the sclera. The mouse model was established by pronuclear microinjection. Transgenic mice and wild-type B6 mice were killed at eight weeks of age. Gene expression levels of LUM and collagen type I...

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Identifiers

PMID: 27711221
DOI: 10.1371/journal.pone.0163165
PMCID: PMC5053428

Genes

LUM

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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