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Scleral remodeling during myopia development in mice eyes: a potential role of thrombospondin-1

14 Feb 2024

Abstract excerpt

BACKGROUND: Scleral extracellular matrix (ECM) remodeling plays a crucial role in the development of myopia, particularly in ocular axial elongation. Thrombospondin-1 (THBS1), also known as TSP-1, is a significant cellular protein involved in matrix remodeling in various tissues. However, the specific role of THBS1 in myopia development remains unclear. METHOD: We employed the HumanNet database to predict genes...

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PMID: 38355399
DOI: 10.1186/s10020-024-00795-x

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