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Article

Targeted expression of a lumican transgene rescues corneal deficiencies in lumican-null mice.

Molecular vision - 18 Oct 2007

Meij Johanna T A, Carlson Eric C, Wang Li, Liu Chia-Yang, Jester James V, Birk David E, Kao Winston W Y

Abstract excerpt

PURPOSE: To investigate whether targeted expression of lumican in the mouse cornea rescued the Lum(-/-) phenotype. METHODS: Lum(-/-)/Kera-Lum mice were generated by crossing Lum(-/-) mice with Kera-Lum transgenic mice that overexpressed lumican under the control of the keratocan promoter. Mouse eyes were analyzed in vivo by confocal microscopy through focusing (CMTF) to determine corneal sublayer thickness and...

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PMID: 17982425

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Related research

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Research trail→

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Targeted expression of a lumican transgene rescues corneal deficiencies in lumican-null mice.PMID 17982425Read ↗

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Role of lumican in the corneal epithelium during wound healing.Semantic proximity Read ↗

Keratocan-deficient mice display alterations in corneal structure.Semantic proximity Read ↗

Enlargement of the Axial Length and Altered Ultrastructural Features of the Sclera in a Mutant Lumican Transgenic Mouse Model.Semantic proximity Read ↗

Role of Cys41 in the N-terminal domain of lumican in ex vivo collagen fibrillogenesis by cultured corneal stromal cells.Semantic proximity Read ↗

Knockdown of Zebrafish Lumican Gene (zlum) Causes Scleral Thinning and Increased Size of Scleral CoatsSemantic proximity Read ↗

Response of Lens Epithelial Cells to Injury: Role of Lumican in Epithelial-Mesenchymal TransitionSemantic proximity Read ↗

An x-ray diffraction investigation of corneal structure in lumican-deficient mice.Semantic proximity Read ↗

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