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Article

Human Pro370Leu Mutant Myocilin Induces the Phenotype of Open-Angle Glaucoma in Transgenic Mice.

Cellular and molecular neurobiology - 1 Jul 2023

Cheng Ying, Wu Shen, Yan Xuejing, Liu Qian, Lin Danting, Zhang Jingxue, Wang Ningli

Abstract excerpt

To investigate the characteristics of mutation myocilin proteins and glaucoma pathological phenotype in transgenic mice with full-length human Pro370Leu mutant myocilin gene (Tg-MYOCP370L). Tg-MYOCP370L mice were established using the CRISPR/Cas9 system. Long-term intraocular pressure (IOP) was measured, myocilin protein expressions in anterior chamber angle, retina, optic nerve tissues and aqueous humor were...

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PMID: 36069958
DOI: 10.1007/s10571-022-01280-x

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