Article
Altered collagen fibril formation in the sclera of lumican-deficient mice.
Investigative ophthalmology & visual science - 1 Jun 2002
Austin Bobbie A, Coulon Christopher, Liu Chia-Yang, Kao Winston W-Y, Rada Jody A
Abstract excerpt
PURPOSE: To better understand the role of lumican (corneal keratan sulfate proteoglycan) in the scleral extracellular matrix, collagen fibril size, shape, and organization were evaluated in the sclera of wild-type mice and in mice homozygous or heterozygous for a null mutation in the lumican gene. METHODS. Anterior and posterior sclera from 6-month-old wild-type (lum+/lum+) and lumican-deficient mice (lum+/lum-...
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