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Article

Exclusion of lumican and fibromodulin as candidate genes in MYP3 linked high grade myopia.

Molecular vision - 30 Nov 2004

Paluru Prasuna C, Scavello Genaro S, Ganter William R, Young Terri L

Abstract excerpt

PURPOSE: The proteoglycans lumican and fibromodulin regulate collagen fibril assembly and show expression in ocular tissues. A recent mouse knockout study implicates lumican and fibromodulin as functional candidate genes for high myopia. Lumican maps within the chromosome 12q21-q23 autosomal dominant high grade myopia-3 (MYP3) interval, and fibromodulin maps to chromosome 1q32. We screened individuals for lumican...

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PMID: 15592176

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Exclusion of lumican and fibromodulin as candidate genes in MYP3 linked high grade myopia.PMID 15592176Read ↗

Evaluation of proteoglycan gene polymorphisms as risk factors in the genetic susceptibility to high myopia.Semantic proximity Read ↗

Novel mutations in the small leucine-rich repeat protein/proteoglycan (SLRP) genes in high myopiaSemantic proximity Read ↗

Ocular and Scleral Alterations in Gene-Targeted Lumican-Fibromodulin Double-Null MiceSemantic proximity Read ↗

The association of haplotype at the lumican gene with high myopia susceptibility in Taiwanese patients.Semantic proximity Read ↗

Association of the lumican gene functional 3'-UTR polymorphism with high myopia.Semantic proximity Read ↗

Functions of lumican and fibromodulin: lessons from knockout mice.Semantic proximity Read ↗

Association mapping of the high-grade myopia MYP3 locus reveals novel candidates UHRF1BP1L, PTPRR, and PPFIA2.Semantic proximity Read ↗

Refinement of the MYP3 locus on human chromosome 12 in a German family with Mendelian autosomal dominant high-grade myopia by SNP array mapping.Semantic proximity Read ↗

Evaluation of Lipin 2 as a candidate gene for autosomal dominant 1 high-grade myopia.Semantic proximity Read ↗

Enlargement of the Axial Length and Altered Ultrastructural Features of the Sclera in a Mutant Lumican Transgenic Mouse Model.Semantic proximity Read ↗

Sequence variants in the transforming growth beta-induced factor (TGIF) gene are not associated with high myopia.Semantic proximity Read ↗

PSMD3 gene mutations cause pathological myopia.Semantic proximity Read ↗

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