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Article

[Regulation of bFGF and TGF-β2 in human scleral fibroblasts by the lumican gene mutation associated with myopia].

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology - 11 Apr 2021

Lyu X T, Song Y Z, Zhang F J

Abstract excerpt

Objective: To investigate the regulation of basic fibroblast growth factor (bFGF) and transforming growth factor (TGF)-β2 in human scleral fibroblasts (HSFs) by the adenovirus-mediated Lumican gene mutation, and to illustrate the effect of this mutation on myopia. Methods: Experimental study. The HSFs were isolated and cultured from human scleral tissues. The 3rd to 5th generation HSFs were transduced with...

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PMID: 33832052
DOI: 10.3760/cma.j.cn112142-20200825-00553

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