Article
Foxg1-Cre Mediated Lrp2 Inactivation in the Developing Mouse Neural Retina, Ciliary and Retinal Pigment Epithelia Models Congenital High Myopia.
PloS one - 1 Jan 2015
Cases Olivier, Joseph Antoine, Obry Antoine, Santin Mathieu D, Ben-Yacoub Sirine, Pâques Michel, Amsellem-Levera Sabine, Bribian Ana, Simonutti Manuel, Augustin Sébastien, Debeir Thomas, Sahel José Alain, Christ Annabel, de Castro Fernando, Lehéricy Stéphane, Cosette Pascal, Kozyraki Renata
Abstract excerpt
Myopia is a common ocular disorder generally due to increased axial length of the eye-globe. Its extreme form high myopia (HM) is a multifactorial disease leading to retinal and scleral damage, visual impairment or loss and is an important health issue. Mutations in the endocytic receptor LRP2 gene result in Donnai-Barrow (DBS) and Stickler syndromes, both characterized by HM. To clearly establish the link...
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