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Article

Lrpap1 deficiency leads to myopia through TGF-β-induced apoptosis in zebrafish

19 Oct 2022

Abstract excerpt

BACKGROUND: Frameshift mutations in LRPAP1 are responsible for autosomal recessive high myopia in human beings but its underlying mechanism remains elusive. This study aims to investigate the effect of LRPAP1 defect on ocular refractive development and its involved mechanism. METHODS: A lrpap1 mutant zebrafish line with homozygous frameshift mutation was generated by CRISPR/Cas9 technology and confirmed by Sanger...

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PMID: 36261846
DOI: 10.1186/s12964-022-00970-9

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