Article
PTTG1IP and MAML3, novel genomewide association study genes for severity of hyperresponsiveness in adult asthma.
Allergy - 1 May 2017
Nieuwenhuis M A E, Vonk J M, Himes B E, Sarnowski C, Minelli C, Jarvis D, Bouzigon E, Nickle D C, Laviolette M, Sin D, Weiss S T, van den Berge M, Koppelman G H, Postma D S
Abstract excerpt
BACKGROUND: The severity of bronchial hyperresponsiveness (BHR) is a fundamental feature of asthma. The severity of BHR varies between asthmatics and is associated with lack of asthma control. The mechanisms underlying this trait are still unclear. This study aimed to identify genes associated with BHR severity, using a genomewide association study (GWAS) on the slope of BHR in adult asthmatics. METHODS: We...
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