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Article

Network study of nasal transcriptome profiles reveals master regulator genes of asthma.

The Journal of allergy and clinical immunology - 1 Mar 2021

Do Anh N, Chun Yoojin, Grishina Galina, Grishin Alexander, Rogers Angela J, Raby Benjamin A, Weiss Scott T, Vicencio Alfin, Schadt Eric E, Bunyavanich Supinda

Abstract excerpt

BACKGROUND: Nasal transcriptomics can provide an accessible window into asthma pathobiology. OBJECTIVE: Our goal was to move beyond gene signatures of asthma to identify master regulator genes that causally regulate genes associated with asthma phenotypes. METHODS: We recruited 156 children with severe persistent asthma and controls for nasal transcriptome profiling and applied network-based and probabilistic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32828590
DOI: 10.1016/j.jaci.2020.07.006
PMCID: PMC7892642

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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