Article
Susceptibility to chronic mucus hypersecretion, a genome wide association study.
PloS one - 1 Jan 2014
Dijkstra Akkelies E, Smolonska Joanna, van den Berge Maarten, Wijmenga Ciska, Zanen Pieter, Luinge Marjan A, Platteel Mathieu, Lammers Jan-Willem, Dahlback Magnus, Tosh Kerrie, Hiemstra Pieter S, Sterk Peter J, Spira Avi, Vestbo Jorgen, Nordestgaard Borge G, Benn Marianne, Nielsen Sune F, Dahl Morten, Verschuren W Monique, Picavet H Susan J, Smit Henriette A, Owsijewitsch Michael, Kauczor Hans U, de Koning Harry J, Nizankowska-Mogilnicka Eva, Mejza Filip, Nastalek Pawel, van Diemen Cleo C, Cho Michael H, Silverman Edwin K, Crapo James D, Beaty Terri H, Lomas David A, Bakke Per, Gulsvik Amund, Bossé Yohan, Obeidat Ma'en, Obeidat M A, Loth Daan W, Lahousse Lies, Rivadeneira Fernando, Uitterlinden Andre G, Hofman Andre, Stricker Bruno H, Brusselle Guy G, van Duijn Cornelia M, Brouwer Uilke, Koppelman Gerard H, Vonk Judith M, Nawijn Martijn C, Groen Harry J M, Timens Wim, Boezen H Marike, Postma Dirkje S
Abstract excerpt
BACKGROUND: Chronic mucus hypersecretion (CMH) is associated with an increased frequency of respiratory infections, excess lung function decline, and increased hospitalisation and mortality rates in the general population. It is associated with smoking, but it is unknown why only a minority of smokers develops CMH. A plausible explanation for this phenomenon is a predisposing genetic constitution. Therefore, we...
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