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Article

A common cortactin gene variation confers differential susceptibility to severe asthma.

Genetic epidemiology - 1 Dec 2008

Ma Shwu-Fan, Flores Carlos, Wade Michael S, Dudek Steven M, Nicolae Dan L, Ober Carole, Garcia Joe G N

Abstract excerpt

Genomic regions with replicated linkage to asthma-related phenotypes likely harbor multiple susceptibility loci with relatively minor effects on disease susceptibility. The 11q13 chromosomal region has repeatedly been linked to asthma with five genes residing in this region with reported replicated associations. Cortactin, an actin-binding protein encoded by the CTTN gene in 11q13, constitutes a key regulator of...

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Identifiers

PMID: 18521921
DOI: 10.1002/gepi.20343
PMCID: PMC3774307

Genes

CTTN
MYLK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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