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Article

Genetic analyses identify GSDMB associated with asthma severity, exacerbations, and antiviral pathways.

The Journal of allergy and clinical immunology - 1 Mar 2021

Li Xingnan, Christenson Stephanie A, Modena Brian, Li Huashi, Busse William W, Castro Mario, Denlinger Loren C, Erzurum Serpil C, Fahy John V, Gaston Benjamin, Hastie Annette T, Israel Elliot, Jarjour Nizar N, Levy Bruce D, Moore Wendy C, Woodruff Prescott G, Kaminski Naftali, Wenzel Sally E, Bleecker Eugene R, Meyers Deborah A

Abstract excerpt

BACKGROUND: The Chr17q12-21.2 region is the strongest and most consistently associated region with asthma susceptibility. The functional genes or single nucleotide polymorphisms (SNPs) are not obvious due to linkage disequilibrium. OBJECTIVES: We sought to comprehensively investigate whole-genome sequence and RNA sequence from human bronchial epithelial cells to dissect functional genes/SNPs for asthma severity...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32795586
DOI: 10.1016/j.jaci.2020.07.030
PMCID: PMC7876167

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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