Article
Examination of the relationship between variation at 17q21 and childhood wheeze phenotypes.
The Journal of allergy and clinical immunology - 1 Mar 2013
Granell Raquel, Henderson A John, Timpson Nicholas, St Pourcain Beate, Kemp John P, Ring Susan M, Ho Karen, Montgomery Stephen B, Dermitzakis Emmanouil T, Evans David M, Sterne Jonathan A C
Abstract excerpt
BACKGROUND: Genome-wide association studies have identified associations of genetic variants at 17q21 near ORMDL3 with childhood asthma. OBJECTIVES: We sought to determine whether associations in this region are specific to particular asthma phenotypes and specific to ORMDL3. METHODS: We examined associations between 244 independent single nucleotide polymorphisms (SNPs) plus 13 previously identified...
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