Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Imatinib attenuates cerebrovascular injury and phenotypic transformation after intracerebral hemorrhage in rats.

American journal of physiology. Regulatory, integrative and comparative physiology - 1 Dec 2016

Pearce William J, Doan Coleen, Carreon Desirelys, Kim Dahlim, Durrant Lara M, Manaenko Anatol, McCoy Lauren, Obenaus Andre, Zhang John H, Tang Jiping

Abstract excerpt

This study explored the hypothesis that intracerebral hemorrhage (ICH) promotes release of diffusible factors that can significantly influence the structure and function of cerebral arteries remote from the site of injury, through action on platelet-derived growth factor (PDGF) receptors. Four groups of adult male Sprague-Dawley rats were studied (n = 8 each): 1) sham; 2) sham + 60 mg/kg ip imatinib; 3) ICH...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cerebral Arteries
Share to Cerebral Hemorrhage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cerebrovascular Circulation

Share to Cerebrovascular Disorders

Share to Dose-Response Relationship, Drug

Share to Imatinib Mesylate

Share to Rats, Sprague-Dawley

Share to Receptors, Platelet-Derived Growth Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 27707720
DOI: 10.1152/ajpregu.00240.2016
PMCID: PMC5256978

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Imatinib attenuates cerebrovascular injury and phenotypic transformation after intracerebral hemorrhage in rats.PMID 27707720Read ↗

Phenotypic transformation of smooth muscle in vasospasm after aneurysmal subarachnoid hemorrhage.Semantic proximity Read ↗

Platelet-Derived Growth Factor Receptor-β Regulates Vascular Smooth Muscle Cell Phenotypic Transformation and Neuroinflammation After Intracerebral Hemorrhage in Mice.Semantic proximity Read ↗

Reduced myofibroblast transdifferentiation and fibrotic scarring in ischemic stroke after imatinib treatmentSemantic proximity Read ↗

Adult organotypic brain slice cultures recapitulate extracellular matrix remodelling in haemorrhagic strokeSemantic proximity Read ↗

What Is the Role of the Rho-ROCK Pathway in Neurologic Disorders?Semantic proximity Read ↗

Pharmacological inhibition of epidermal growth factor receptor attenuates intracranial aneurysm formation by modulating the phenotype of vascular smooth muscle cells.Semantic proximity Read ↗

Chronic alcohol exposure induces cerebral microbleeds by TGF-β1/Smad signaling pathway mediated remodeling of cerebral small vesselsSemantic proximity Read ↗

Recombinant Osteopontin Stabilizes Smooth Muscle Cell Phenotype via Integrin Receptor/Integrin-Linked Kinase/Rac-1 Pathway After Subarachnoid Hemorrhage in Rats.Semantic proximity Read ↗

Smooth Muscle Dysfunction Drives Cerebrovascular Reserve Failure and End-Organ Brain InjurySemantic proximity Read ↗

Insulin-like growth factor 1 deficiency exacerbates hypertension-induced cerebral microhemorrhages in mice, mimicking the aging phenotype.Semantic proximity Read ↗

TRPV1 attenuates intracranial arteriole remodeling through inhibiting VSMC phenotypic modulation in hypertension.Semantic proximity Read ↗

Electromechanical alterations in the cerebrovasculature of stroke-prone rats.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.