Article
Platelet-Derived Growth Factor Receptor-β Regulates Vascular Smooth Muscle Cell Phenotypic Transformation and Neuroinflammation After Intracerebral Hemorrhage in Mice.
Critical care medicine - 1 Jun 2016
Yang Peng, Wu Jiang, Miao Liyan, Manaenko Anatol, Matei Nathanael, Zhang Yang, Xu Liang, Pearce William J, Hartman Richard E, Obenaus Andre, Zhang John H, Xu Feng, Tang Jiping
Abstract excerpt
OBJECTIVE: Platelet-derived growth factor-BB activates platelet-derived growth factor receptor-β and promotes vascular smooth muscle cell phenotypic transformation. Elevated levels of non-muscle myosin IIB (SMemb) are found in secretory smooth muscle cells along with inflammatory mediators, such as intercellular adhesion molecule-1, which can amplify neutrophil infiltration into the brain. In the present study,...
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