Article

Reduced myofibroblast transdifferentiation and fibrotic scarring in ischemic stroke after imatinib treatment

2021-10-28

Abstract excerpt

The tyrosine kinase inhibitor imatinib has been reported to improve outcome in patients following ischemic stroke but the exact mechanism remains elusive. Here, utilizing a photothrombotic murine model of middle cerebral artery occlusion (MCAO), we show that imatinib-mediated inhibition of stroke-induced blood-brain barrier (BBB) dysfunction coincided with decreased expression of genes associated with inflammation...

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Literature Corpus work: faaccbba-5b70-501c-9e69-c286d7a4d828
DOI: 10.1101/2021.10.28.466225

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