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Article

Pharmacological inhibition of epidermal growth factor receptor attenuates intracranial aneurysm formation by modulating the phenotype of vascular smooth muscle cells.

CNS neuroscience & therapeutics - 1 Jan 2022

Luo Yin, Tang Haishuang, Zhang Zhaolong, Zhao Rui, Wang Chuanchuan, Hou Wenguang, Huang Qinghai, Liu Jianmin

Abstract excerpt

AIM: To study the effect of pharmacological inhibition of epidermal growth factor receptor (EGFR) on intracranial aneurysm (IA) initiation. METHODS: Human IA samples were analyzed for the expression of p-EGFR and alpha smooth muscle actin (α-SMA) by immunofluorescence (IF). Rat models of IA were established to evaluate the ability of the EGFR inhibitor, erlotinib, to attenuate the incidence of IA. We analyzed...

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Identifiers

PMID: 34729926
DOI: 10.1111/cns.13735
PMCID: PMC8673708

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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