Article
Recombinant Osteopontin Stabilizes Smooth Muscle Cell Phenotype via Integrin Receptor/Integrin-Linked Kinase/Rac-1 Pathway After Subarachnoid Hemorrhage in Rats.
Stroke - 1 May 2016
Wu Jiang, Zhang Yang, Yang Peng, Enkhjargal Budbazar, Manaenko Anatol, Tang Jiping, Pearce William J, Hartman Richard, Obenaus Andre, Chen Gang, Zhang John H
Abstract excerpt
BACKGROUND AND PURPOSE: Recombinant osteopontin (rOPN) has been reported to be neuroprotective in stroke animal models. The purpose of this study is to investigate a potential role and mechanism of nasal administration of rOPN on preserving the vascular smooth muscle phenotype in early brain injury after subarachnoid hemorrhage (SAH). METHODS: One hundred and ninety-two male adult Sprague-Dawley rats were used....
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