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Insulin-like growth factor 1 deficiency exacerbates hypertension-induced cerebral microhemorrhages in mice, mimicking the aging phenotype.

Aging cell - 1 Jun 2017

Tarantini Stefano, Valcarcel-Ares Noa M, Yabluchanskiy Andriy, Springo Zsolt, Fulop Gabor A, Ashpole Nicole, Gautam Tripti, Giles Cory B, Wren Jonathan D, Sonntag William E, Csiszar Anna, Ungvari Zoltan

Abstract excerpt

Clinical and experimental studies show that aging exacerbates hypertension-induced cerebral microhemorrhages (CMHs), which progressively impair neuronal function. There is growing evidence that aging promotes insulin-like growth factor 1 (IGF-1) deficiency, which compromises multiple aspects of cerebromicrovascular and brain health. To determine the role of IGF-1 deficiency in the pathogenesis of CMHs, we induced...

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PMID: 28295976
DOI: 10.1111/acel.12583
PMCID: PMC5418199

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