What Is the Role of the Rho-ROCK Pathway in Neurologic Disorders?

doi:10.1212/wnl.0000000000207779

Article

What Is the Role of the Rho-ROCK Pathway in Neurologic Disorders?

13 Sept 2023

Abstract excerpt

Rho-associated coiled-coil containing kinases (ROCK), including ROCK1 and ROCK2, are the primary effectors of the Rho family of small guanosine triphosphatases (GTPases)1 (Figure). The Rho/ROCK signaling pathway has a critical role in regulating the cytoskeleton dynamics responsible for cell adhesion, proliferation, motility, and contraction.2,3 In the nervous system, ROCK proteins phosphorylate a wide variety of...

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