Article

Smooth Muscle Dysfunction Drives Cerebrovascular Reserve Failure and End-Organ Brain Injury

2026-01-26

Abstract excerpt

<h4>Background</h4> Failure of cerebrovascular reserve is a fundamental determinant of ischemic vulnerability, yet the mechanisms by which vascular smooth muscle dysfunction compromises reserve and predisposes the brain to injury remain incompletely defined. We therefore tested whether a pathogenic smooth muscle mutation produces a baseline failure of cerebrovascular reserve sufficient to render the brain vulnera...

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Literature Corpus work: beac9687-a700-51be-b83e-6d769dfa6418
DOI: 10.64898/2026.01.26.701890

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