Loss of interleukin-10 signaling and infantile inflammatory bowel disease: implications for diagnosis and therapy.

doi:10.1053/j.gastro.2012.04.045

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Article

Loss of interleukin-10 signaling and infantile inflammatory bowel disease: implications for diagnosis and therapy.

Gastroenterology - 1 Aug 2012

Kotlarz Daniel, Beier Rita, Murugan Dhaarini, Diestelhorst Jana, Jensen Ole, Boztug Kaan, Pfeifer Dietmar, Kreipe Hans, Pfister Eva-Doreen, Baumann Ulrich, Puchalka Jacek, Bohne Jens, Egritas Odul, Dalgic Buket, Kolho Kaija-Leena, Sauerbrey Axel, Buderus Stephan, Güngör Tayfun, Enninger Axel, Koda Yu Kar Ling, Guariso Graziella, Weiss Batia, Corbacioglu Selim, Socha Piotr, Uslu Nuray, Metin Ayse, Wahbeh Ghassan T, Husain Khalid, Ramadan Dina, Al-Herz Waleed, Grimbacher Bodo, Sauer Martin, Sykora Karl-Walter, Koletzko Sibylle, Klein Christoph

Abstract excerpt

BACKGROUND & AIMS: Homozygous loss of function mutations in interleukin-10 (IL10) and interleukin-10 receptors (IL10R) cause severe infantile (very early onset) inflammatory bowel disease (IBD). Allogeneic hematopoietic stem cell transplantation (HSCT) was reported to induce sustained remission in 1 patient with IL-10R deficiency. We investigated heterogeneity among patients with very early onset IBD, its...

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PMID: 22549091
DOI: 10.1053/j.gastro.2012.04.045

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