Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel variants of the IL-10 receptor 1 affect inhibition of monocyte TNF-alpha production.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 2003

Gasche Christoph, Grundtner Paul, Zwirn Petra, Reinisch Walter, Shaw Sarah H, Zdanov Alexander, Sarma Usha, Williams Lynn M, Foxwell Brian M, Gangl Alfred

Abstract excerpt

IL-10-deficient mice exhibit spontaneous enterocolitis and other symptoms akin to Crohn's disease, indicating that IL-10 might regulate normal physiology in the gut. However, clinical trials with IL-10 in Crohn's disease were disappointing, although some patients showed healing of intestinal mucosa. This study searched for genetic polymorphisms within the IL-10 pathway. We decided to screen for mutations of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arginine
Share to Crohn Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycine

Share to Interleukin-10

Share to Macromolecular Substances

Share to Monocytes

Share to Receptors, Interleukin

Share to Serine

Source

Identifiers

PMID: 12759436
DOI: 10.4049/jimmunol.170.11.5578

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel variants of the IL-10 receptor 1 affect inhibition of monocyte TNF-alpha production.PMID 12759436Read ↗

The IL-10R1 S138G loss-of-function allele and ulcerative colitis.Semantic proximity Read ↗

A Comprehensive Review of IL-10 and IL-10 Receptor Deficiencies: From Basic Science to Clinical Bedside.Semantic proximity Read ↗

Phenotypic characterization of very early-onset IBD due to mutations in the IL10, IL10 receptor alpha or beta gene: a survey of the Genius Working Group.Semantic proximity Read ↗

Exome sequencing identifies novel compound heterozygous mutations of IL-10 receptor 1 in neonatal-onset Crohn's disease.Semantic proximity Read ↗

The clinical, molecular, and therapeutic features of patients with IL10/IL10R deficiency: a systematic review.Semantic proximity Read ↗

IL10R1 loss-of-function alleles in rheumatoid arthritis and systemic lupus erythematosus.Semantic proximity Read ↗

Homozygosity of the interleukin-10 receptor 1 G330R allele is associated with schizophrenia.Semantic proximity Read ↗

In-silico analysis unravels the structural and functional consequences of non-synonymous SNPs in the human IL-10 geneSemantic proximity Read ↗

Interleukin 1β Mediates Intestinal Inflammation in Mice and Patients With Interleukin 10 Receptor Deficiency.Semantic proximity Read ↗

Very early onset inflammatory bowel disease: Investigation of the IL-10 signaling pathway in Iranian children.Semantic proximity Read ↗

Alterations in T and B Cell Receptor Repertoires Patterns in Patients With IL10 Signaling Defects and History of Infantile-Onset IBD.Semantic proximity Read ↗

Inflammatory bowel disease and mutations affecting the interleukin-10 receptor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.