Article

Determining distinct roles of IL-1α through generation of an IL-1α knockout mouse with no defect in IL-1β expression

2022-09-21

Abstract excerpt

<h4>ABSTRACT</h4> Interleukin 1α (IL-1α) and IL-1β are the founding members of the IL-1 cytokine family, and these innate immune inflammatory mediators are critically important in health and disease. Early studies on these molecules suggested that their expression was interdependent, with an initial genetic model of IL-1α depletion, the IL-1α KO mouse ( Il1a -KO line1 ), showing reduced IL-1β expression. Howeve...

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Literature Corpus work: d9453f04-8079-5550-b77f-79ab7acc02a0
DOI: 10.1101/2022.09.21.508892

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