Article
Phenotypic Characterization of Very Early-Onset Inflammatory Bowel Disease with Interleukin-10 Signaling Deficiency: Based on a Large Cohort Study.
Inflammatory bowel diseases - 14 Mar 2019
Zheng Cuifang, Huang Ying, Hu Wenhui, Shi Jieru, Ye Ziqing, Qian Xiaowen, Huang Zhiheng, Xue Aijuan, Wang Yuhuan, Lu Junping, Tang Zifei, Wu Jie, Wang Lin, Peng Kaiyue, Zhou Ying, Miao Shijian, Sun Hua
Abstract excerpt
BACKGROUND: Interleukin-10 (IL10)/interleukin-10 receptor (IL10R) deficiency is a rare disease with life-threatening infantile-onset colitis. We sought to accurately phenotype this disorder based on a large cohort of patients with a proven defect of IL10 signaling and to clarify the effects of allogeneic hematopoietic stem cell transplantation (HSCT). METHODS: We analyzed the phenotypes of our 61 patients and...
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