Article
Inflammatory bowel disease and mutations affecting the interleukin-10 receptor.
The New England journal of medicine - 19 Nov 2009
Glocker Erik-Oliver, Kotlarz Daniel, Boztug Kaan, Gertz E Michael, Schäffer Alejandro A, Noyan Fatih, Perro Mario, Diestelhorst Jana, Allroth Anna, Murugan Dhaarini, Hätscher Nadine, Pfeifer Dietmar, Sykora Karl-Walter, Sauer Martin, Kreipe Hans, Lacher Martin, Nustede Rainer, Woellner Cristina, Baumann Ulrich, Salzer Ulrich, Koletzko Sibylle, Shah Neil, Segal Anthony W, Sauerbrey Axel, Buderus Stephan, Snapper Scott B, Grimbacher Bodo, Klein Christoph
Abstract excerpt
BACKGROUND: The molecular cause of inflammatory bowel disease is largely unknown. METHODS: We performed genetic-linkage analysis and candidate-gene sequencing on samples from two unrelated consanguineous families with children who were affected by early-onset inflammatory bowel disease. We screened six additional patients with early-onset colitis for mutations in two candidate genes and carried out functional...
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