Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of IL-10 signaling in macrophages limits bacterial killing driven by prostaglandin E2.

The Journal of experimental medicine - 3 Feb 2020

Mukhopadhyay Subhankar, Heinz Eva, Porreca Immacolata, Alasoo Kaur, Yeung Amy, Yang Huei-Ting, Schwerd Tobias, Forbester Jessica L, Hale Christine, Agu Chukwuma A, Choi Yoon Ha, Rodrigues Julia, Capitani Melania, Jostins-Dean Luke, Thomas David C, Travis Simon, Gaffney Daniel, Skarnes William C, Thomson Nicholas, Uhlig Holm H, Dougan Gordon, Powrie Fiona

Abstract excerpt

Loss of IL-10 signaling in macrophages (Mφs) leads to inflammatory bowel disease (IBD). Induced pluripotent stem cells (iPSCs) were generated from an infantile-onset IBD patient lacking a functional IL10RB gene. Mφs differentiated from IL-10RB-/- iPSCs lacked IL-10RB mRNA expression, were unable to phosphorylate STAT3, and failed to reduce LPS induced inflammatory cytokines in the presence of exogenous IL-10....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dinoprostone
Share to Gene Knockout Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Inflammatory Bowel Diseases

Share to Interleukin-10

Share to Lipopolysaccharides

Share to Macrophage Activation

Share to Salmonella typhimurium

Share to STAT3 Transcription Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 31819956
DOI: 10.1084/jem.20180649
PMCID: PMC7041704

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of IL-10 signaling in macrophages limits bacterial killing driven by prostaglandin E2.PMID 31819956Read ↗

Genetic Correction of IL-10RB Deficiency Reconstitutes Anti-Inflammatory Regulation in iPSC-Derived MacrophagesSemantic proximity Read ↗

Knockout-Induced Pluripotent Stem Cells for Disease and Therapy Modeling of IL-10-Associated Primary ImmunodeficienciesSemantic proximity Read ↗

Interleukin-22 promotes phagolysosomal fusion to induce protection against Salmonella enterica Typhimurium in human epithelial cellsSemantic proximity Read ↗

Macrophages in Ulcerative Colitis: Immunomodulatory Roles, Phenotypic Switching, and Therapeutic Targeting.Semantic proximity Read ↗

Macrophage polarization in inflammatory bowel disease.Semantic proximity Read ↗

Krüppel-like factor KLF10 deficiency predisposes to colitis through colonic macrophage dysregulation.Semantic proximity Read ↗

Macrophage polarization: an effective approach to targeted therapy of inflammatory bowel disease.Semantic proximity Read ↗

Eicosatetraynoic Acid Regulates Pro-Fibrotic Pathways in an Induced Pluripotent Stem Cell Derived Macrophage:Human Intestinal Organoid Model of Crohn’s DiseaseSemantic proximity Read ↗

E4BP4 in macrophages induces an anti-inflammatory phenotype that ameliorates the severity of colitis.Semantic proximity Read ↗

Interleukin 1β Mediates Intestinal Inflammation in Mice and Patients With Interleukin 10 Receptor Deficiency.Semantic proximity Read ↗

E4BP4 in macrophages induces an anti-inflammatory phenotype that ameliorates the severity of colitisSemantic proximity Read ↗

Loss of interleukin-10 signaling and infantile inflammatory bowel disease: implications for diagnosis and therapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.