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Article

BMP4 promotes a phenotype change of an esophageal squamous epithelium via up-regulation of KLF4.

Experimental and molecular pathology - 1 Oct 2016

Yan Wu, Zhang Haoxiang, Li Jingwen, Shen Caifei, Xia Yiju, Wang Pu, Zhang Yafei, Feng Ji, Shao Shunzi, Yu Xiaona, Fang Dianchun

Abstract excerpt

INTRODUCTION: Barrett's esophagus is a metaplastic lesion. However, the cellular and molecular mechanisms involved are poorly understood. The aim of this study was to investigate the roles of KLF4 and BMP4 in the pathogenesis of Barrett's epithelium. MATERIALS AND METHODS: Immunohistochemistry was used to analyse the expression of KLF4, BMP4, CDX2, MUC2 and MUC5AC in human esophageal specimens. Human esophageal...

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Source

Identifiers

PMID: 27693253
DOI: 10.1016/j.yexmp.2016.09.007

Genes

KLF4
BMP4
CDX2
MUC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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