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Article

BMP4 Signaling Is Able to Induce an Epithelial-Mesenchymal Transition-Like Phenotype in Barrett's Esophagus and Esophageal Adenocarcinoma through Induction of SNAIL2.

PloS one - 1 Jan 2016

Kestens Christine, Siersema Peter D, Offerhaus G Johan A, van Baal Jantine W P M

Abstract excerpt

BACKGROUND: Bone morphogenetic protein 4 (BMP4) signaling is involved in the development of Barrett's esophagus (BE), a precursor of esophageal adenocarcinoma (EAC). In various cancers, BMP4 has been found to induce epithelial-mesenchymal transition (EMT) but its function in the development of EAC is currently unclear. AIM: To investigate the expression of BMP4 and several members of the BMP4 pathway in EAC....

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Source

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Identifiers

PMID: 27191723
DOI: 10.1371/journal.pone.0155754
PMCID: PMC4871520

Genes

BMP4
CDH1
CDH2
SMAD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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