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Article

Aberrant epithelial-mesenchymal Hedgehog signaling characterizes Barrett's metaplasia.

Gastroenterology - 1 May 2010

Wang David H, Clemons Nicholas J, Miyashita Tomoharu, Dupuy Adam J, Zhang Wei, Szczepny Anette, Corcoran-Schwartz Ian M, Wilburn Daniel L, Montgomery Elizabeth A, Wang Jean S, Jenkins Nancy A, Copeland Neal A, Harmon John W, Phillips Wayne A, Watkins D Neil

Abstract excerpt

BACKGROUND & AIMS: The molecular mechanism underlying epithelial metaplasia in Barrett's esophagus remains unknown. Recognizing that Hedgehog signaling is required for early esophageal development, we sought to determine if the Hedgehog pathway is reactivated in Barrett's esophagus, and if genes...

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Source

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Identifiers

PMID: 20138038
DOI: 10.1053/j.gastro.2010.01.048
PMCID: PMC3422577

Genes

BMP4
SOX9
PTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20138038-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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