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Article

Loss of Klf4 in mice causes altered proliferation and differentiation and precancerous changes in the adult stomach.

Gastroenterology - 1 Apr 2005

Katz Jonathan P, Perreault Nathalie, Goldstein Bree G, Actman Lori, McNally Sara R, Silberg Debra G, Furth Emma E, Kaestner Klaus H

Abstract excerpt

BACKGROUND & AIMS: The epithelial zinc-finger transcription factor Klf4 (formerly GKLF) regulates cellular proliferation and differentiation in vitro. Klf4 null mice die by postnatal day 1 and show changes in epithelial differentiation of skin and colon. METHODS: We used tissue-specific gene ablation to generate mice lacking Klf4 in their gastric epithelia. Klf4 mutant mice and controls were killed for histology,...

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Source

Identifiers

PMID: 15825076
DOI: 10.1053/j.gastro.2005.02.022

Genes

KLF4
TFF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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