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Article

Acid, Bile, and CDX: the ABCs of making Barrett's metaplasia

13 Jun 2008

Abstract excerpt

Barrett's esophagus, a squamous-to-columnar cell metaplasia that develops as a result of chronic gastroesophageal reflux disease (GERD), is a risk factor for esophageal adenocarcinoma. The molecular events underlying the pathogenesis of Barrett's metaplasia are poorly understood, but recent studies suggest that interactions among developmental signaling pathways, morphogenetic factors, and Caudal homeobox (Cdx)...

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Identifiers

PMID: 18556417
DOI: 10.1152/ajpgi.90250.2008

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